NATURAL SUPPRESSOR CELLS IN HUMAN LEPROSY - THE ROLE OF HLA-D-IDENTICAL PERIPHERAL LYMPHOCYTES AND MACROPHAGES IN THE INVITRO MODULATION OF LYMPHOPROLIFERATIVE RESPONSES

Abstract

Six [human] families with HLA-D-identical siblings suffering from leprosy were studied. Lymphocytes and marcophages isolated from the peripheral blood were co-cultured with allogeneic, HLA-D-identical cells and stimulated with Mycobacterium leprae antigens and concanavalin A. Tuberculoid patients had circulating lymphocytes which showed marked functional suppression of lymphoproliferative responses to antigen and mitogen. Lepromatous patients showed weak lymphocyte suppressor activity. Macrophages derived from responder individuals augmented, while those derived from lepromatous patients inhibited M. leprae-induced proliferation of lymphocytes.