Influence of Cardiopulmonary Bypass on Some Host Defence Functions in Man
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Thoracic and Cardiovascular Surgery
- Vol. 14 (2), 207-211
- https://doi.org/10.3109/14017438009100999
Abstract
Four different functions of the immune defense were studied in 6 men undergoing open-heart surgery with cardiopulmonary bypass (CPB). Preoperatively, a few hours after and 3 days after surgery tests were performed as follows: in vivo phagocytic and metabolic functions of the RES, hemolytic activity of blood monocytes, nitroblue tetrazolium (NBT) reduction by granulocytes and bactericidal capacity of granulocytes. Compared to the preoperative values, the RES functions were unchanged postoperatively, and there was a significant increase in the hemolytic activity of monocytes and in the NBT reduction of granulocytes. The capacity of the granulocytes to kill bacteria was normal a few hours after surgery, but significantly increased on day 3. No infectious complications occurred and all patients recovered uneventfully. Apparently open heart surgery under CPB is accompanied by an increased activity of granulocytes and monocytes in the early postoperative period.This publication has 11 references indexed in Scilit:
- Fasting (Acute Energy Deprivation) in Man: Effect on Polymorphonuclear Granulocyte Functions, Plasma Iron and Serum TransferrinScandinavian Journal of Haematology, 2009
- Effect of Anaesthesia and Open‐Heart Surgery on Lymphocyte Responses to Phytohaemagglutinin and Concanavalin AActa Anaesthesiologica Scandinavica, 1978
- The NBT (Nitroblue Tetrazolium) Activity of Neutrophil Granulocytes in Patients with Influenza A InfectionScandinavian Journal of Infectious Diseases, 1977
- Anesthesia and the Modification of Response to Infection in MiceAnesthesia & Analgesia, 1976
- Stressor exposure and immunological response in man: Interferon-producing capacity and phagocytosisJournal of Psychosomatic Research, 1976
- Lymphocyte Transformation and Changes in Leukocyte CountAnesthesiology, 1975
- Enhanced Phagocytic Capacity THE BIOLOGIC BASIS FOR THE ELEVATED HISTOCHEMICAL NITROBLUE TETRAZOLIUM REACTIONJournal of Clinical Investigation, 1974
- NBT Reduction by Human PhagocytesNew England Journal of Medicine, 1974