Calmodulin bridging of IQ motifs in myosin‐V
- 3 May 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 567 (2-3), 166-170
- https://doi.org/10.1016/j.febslet.2004.04.053
Abstract
Ca2+‐saturated calmodulin binds to double‐length IQ lever‐arm sequences from murine myosin‐V, forming a 1:1 “bridging” complex with very high affinity, (K d2+‐dependent CaM dissociation from the IQ‐region. Structural considerations suggest that formation of the 1:1 complex requires a severe distortion of the lever‐arm, potentially regulating functional motility. This would be consistent with a recent report of diverse, irregular shapes of the lever arm of myosin‐V induced by the presence of Ca2+.This publication has 20 references indexed in Scilit:
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