Fifteen lungs were prepared by fume fixation with alcohol and formalin. The results were unpredictable, but depended mainly on air pressure level and duration of fixation. The chief problems encountered were inability to maintain stable air pressure due to loss of air through visceral pleura when the lung is outside the thorax, areas left unfixed, and overdistention with production of artificial emphysema. This method appears to be impracticable for routine use in surgical or autopsy pathology because of the time required and the unreliability of the results. It is not believed amenable for study and diagnosis of lungs containing destructive and fibrotic disease processes because such changes would tend to inhibit diffusion of fumes of the fixatives. Its chief use appears to be in production of beautiful specimens for demonstrations and study.