The Gamma Globulins

Abstract
ADVANCES in the study of the serum proteins over the past several years have been so extensive that the very term "hypergammaglobulinemia" has a different meaning now from the one it had when first introduced. It is clear that not all antibody molecules have gamma (or "slow") electrophoretic mobility. The recognition that antibody molecules form a family of structurally related species, termed immunoglobulins by Hitzig178 and Heremans,179 has, in essence, expanded the meaning of the term "hypergammaglobulinemia" into "hyperimmunoglobulinemia." We shall use the older designation in the modern sense in this review.Hypergammaglobulinemia is a common finding in a wide . . .