ENCEPHALITIC, IDIOPATHIC AND ARTERIOSCLEROTIC PARKINSONISM

Abstract

The relatively small number of pathologic reports of cases of parkinsonism found in the literature as compared with the unusually large number of clinical reports, especially since the appearance of epidemic encephalitis in 1918, has prompted us to undertake this study. Our principal objects in this investigation were: (1) to put on record a number of additional cases of parkinsonism that have been observed clinically for a long period of years and finally subjected to detailed histologic study, and (2) to determine how far the clinical picture of parkinsonism can be correlated with the anatomic observations, especially as regards the site of the lesions. Ten brains from cases diagnosed, during life, as parkinsonism were selected at random. In three of these the material had been in formaldehyde for years and took the various stains very poorly; this was particularly the case with the globus pallidus. Our report then consists of