Persistence of Antibody after Oral Trivalent Poliovirus Vaccine (Sabin Strains)

Abstract

BECAUSE of the favorable rates of serum-antibody conversion obtained in a pilot study in Elkins, West Virginia, with two feedings of a trivalent oral poliovirus vaccine,¹ the same vaccine was used in a mass vaccination program in Hillsborough County, Florida, in the early spring of 1962.² In the Hillsborough County program 5 different lots of the trivalent vaccine were used. They represented mixtures of 5 consecutive lots of monovalent vaccine of each poliovirus type prepared from the Sabin vaccine strains by Lederle Laboratories in compliance with vaccine-licensing requirements.³ All 15 monovalent lots had passed all the prescribed tests, including . . .