Stromal vascularization in the endometrium during adenomyosis
- 3 February 2003
- journal article
- review article
- Published by Wiley in Microscopy Research and Technique
- Vol. 60 (4), 445-449
- https://doi.org/10.1002/jemt.10282
Abstract
In adenomyosis, the two major frequent symptoms are hypermenorrhea and dysmenorrhea. The incidence of the former is said to be high, ranging from 36 to 70%. It has been found that vascular distribution of the endometrium in adenomyosis is diversely different from fertile patients without adenomyosis. For example, hysteroscopy revealed that approximately half of the patients have abnormal vascularization. In these patients, vascular distribution was generally irregular, and vessels were thick, dilated, and/or reticular in some patients. Moreover, morphometric analysis of the endometrium revealed that in the fertile women, the mean surface area, total surface area, and total number of capillaries, all increased significantly in the secretory phase compared to the proliferative phase. In contrast, the above parameters increased in the adenomyosis group in both the proliferatve phase and secretory phase compared to the fertile women. In particular, the total surface area of capillaries per mm2 markedly rose, by 11.6 times, compared to that of the proliferative phase in the fertile women. These findings suggest that regulatory factors involved in the vascular proliferation are diversely exaggerated, and that the abnormal vascularization of the endometrium is closely related with hypermenorrhea. Microsc. Res. Tech. 60:445–449, 2003.Keywords
This publication has 42 references indexed in Scilit:
- Hysteroscopy and AdenomyosisPublished by S. Karger AG ,2000
- Localization of endothelial nitric oxide synthase messenger ribonucleic acid by in situ hybridization in ectopic endometrial tissue in patients with adenomyosisReproduction, Fertility and Development, 2000
- Is adenomyosis an immune disease?Human Reproduction Update, 1998
- Expression of Aromatase Cytochrome P450 Protein and Messenger Ribonucleic Acid in Human Endometriotic and Adenomyotic Tissues but not in Normal Endometrium1Biology of Reproduction, 1997
- Structure and function of endometrial blood vesselsHuman Reproduction Update, 1996
- Cyclic expression of endothelial nitric oxide synthase mrna in the epithelial glands of human endometriumJournal of the Society for Gynecologic Investigation, 1996
- Adenomyosis must be considered in patients with menorrhagia and a normal-appearing cavity on hysteroscopy or ultrasonographyAmerican Journal of Obstetrics and Gynecology, 1995
- Expression-Activity Profiles of Cells Transfected with Prostaglandin Endoperoxide H Synthase Measured by Quantitative Fluorescence MicroscopyBiochemistry, 1995
- Vascular endothelial growth factor as capillary permeability agent in ovarian hyperstimulation syndromeThe Lancet, 1994
- Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisNature, 1992