A study of HLA antigen association in localized and generalized granuloma annulare

Abstract

HLA‐A and ‐B antigen frequencies were studied in 78 patients, 35 with localized granuloma annulare and 43 with generalized granuloma annulare (GA). Twenty‐eight patients in each group were also typed for HLA‐DR antigens. A group of 200 healthy age‐matched subjects served as controls. HLA‐A31 and B35 were increased significantly in patients with generalized GA, but not in the localized form. HLA‐DR antigen distribution showed no significant variation.