Metabolism of the epoxy resin component 2,2-bis[4-(2,3-epoxypropoxy)phenyl]propane, the diglycidyl ether of bisphenol a (DGEBPA) in the mouse.; Part I. A comparison of the fate of a single dermal application and of a single oral dose of14C-DGEBPA
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 11 (6), 391-399
- https://doi.org/10.3109/00498258109045850
Abstract
1. 14C-DGEBPA dermally applied to mice was only slowly eliminated in the faeces (20% dose) and urine (3%), as a mixture of metabolites, over three days. Most of the applied radioactivity (66% dose) was extracted from the application area and its covering foil. 2. When 14C-DGEBPA was given orally to mice it was rapidly excreted; 80% of the administered 14C was eliminated in the faeces and 11% in the urine 0-3 days after a single oral dose. 3. The urinary and faecal metabolite profiles derived from dermal application and oral dosing were essentially similar.This publication has 5 references indexed in Scilit:
- Metabolism of the epoxy resin component 2,2-bis[4-(2,3-epoxypropoxy)phenyl]propane, the diglycidyl ether of bisphenol a (DGEBPA) in the mouse.; Part II. Identification of metabolites in urine and faeces following a single oral dose of14C-DGEBPAXenobiotica, 1981
- Mutagenic action of a series of epoxidesMutation Research/Genetic Toxicology, 1979
- EPIDERMAL CARCINOGENICITY OF BIS(2,3-EPOXYCYCLOPENTYL)ETHER, 2,2-BIS(PARA-GLYCIDYLOXYPHENYL)PROPANE, AND META-PHENYLENEDIAMINE IN MALE AND FEMALE C3H AND C57BL-6 MICE1979
- Mutagenic action of aromatic epoxy resinsNature, 1978
- Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.Proceedings of the National Academy of Sciences, 1975