From both military and economic aspects, any relatively nontoxic therapy which will shorten the course of a prevalent disease, if even for a few days, is worthy of application. Since it is generally acknowledged that tonsillitis is responsible for a significant number of the total man hours lost to industry and the armed forces, the advisability of treating acute follicular tonsillitis with sulfonamides has been the subject of a variety of studies. From the medical point of view, chemotherapy would be desirable because of the possibility that such complications as peritonsillar abscess and such sequelae of tonsillitis as nephritis and rheumatic fever might be prevented or at least minimized. The advisability of using large doses of sulfonamides (2 Gm. or more per day) in the treatment of tonsillitis remains controversial. Some believe that, since this disease is relatively benign and self limited, chemotherapy is unnecessary and even dangerous.1 This