Effect of atropine and choline on urinary electrolytes

Abstract

Single injections of atropine (0.5 mg/kg) into dogs generally caused some antidiuresis which was accompanied by a reduction in glomerular filtration rate. Atropine-induced antidiuresis may be accompanied by a fall in U_Na and U_Cl. Atropine protected dogs against the toxic action of subsequently infused choline. In seven experiments, choline caused U_pH to rise and U_Na to fall. In five of seven experiments U_K also fell. The action of choline on U_Cl is variable. At high rates of infusion, choline appears to act as an osmotic diuretic.