Blocking Effect of J Chain and J-Chain Antibody on the Binding of Secretory Component to Human IgA and IgM
- 1 December 1975
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 4 (8), 837-842
- https://doi.org/10.1111/j.1365-3083.1975.tb03725.x
Abstract
Isolated released J chain showed only a small affinity for free secretory component (SC), as indicated by a marginal but reproducible blocking effect on the binding of SC to Ig polymers. The SC‐binding site was completely blocked by J‐chain antibody in those Ig polymers where the bound J chains were accessible to the antibody. Along with the established masking effect of SC on the antigenicity of J chains present in secretory IgA, these results are compatible with the idea that the conformation of Ig‐associated J chains contributes to the SC‐binding site of Ig polymers.Keywords
This publication has 21 references indexed in Scilit:
- J Chain in Malignant Human IgG ImmunocytesScandinavian Journal of Immunology, 1975
- Is secretory component disulfide-bonded to both monumer subunits in human secretory IgA dimer?Biochemical and Biophysical Research Communications, 1975
- IgM Reassociation In Vitro: No Influence of J Chain on the Amount of PolymersScandinavian Journal of Immunology, 1974
- Presence of J chain in human immunocytes containing various immunoglobulin classesNature, 1974
- Human Secretory ComponentScandinavian Journal of Immunology, 1974
- Does J chain mediate the combination of 19S IgM and dimeric IgA with the secretory component rather than being necessary for their polymerization?Immunochemistry, 1974
- Reassociation of IgM Subunits in the Presence and Absence of J ChainImmunological Communications, 1973
- Immunoglobulin M and Secretory Immunoglobulin A: Presence of a Common Polypeptide Chain Different from Light ChainsScience, 1971
- In vitro Combination of Human and Bovine Free Secretory Component with IgA of Various SpeciesNature, 1970
- Novel Subunit in Secretory IgANature, 1970