Manifest Psychopathology and Urine Biochemical Measures

Abstract

THE USE of psychiatric rating scales for quantifying symptoms and signs is a recent methodologic refinement in behavioral-biochemical correlative investigations of psychiatric patients. Small-sample longitudinal studies, wherein the patient acts as his own control, have shown a number of interesting psychochemical and psychoendocrine correlations that were not evident with earlier cross-sectional sampling techniques.^1-8Also, multivariate analytic methods now permit both the recognition of intra-individual correlations and the generalization of these correlations into group patterns.⁹In this paper are presented the results of multivariate analyses of changes over time of manifest psychopathology, quantified by a psychiatric rating scale, and multiple urine biochemical measures in manic-depressive patients. This study attempts to exploit the power of multivariate analytic techniques to elucidate the role of biochemical factors in manic-depressive illness. In earlier reports studies of several biochemical measures in manic-depressive illness