Effects of Certain Amino Acids and Related Compounds on Propagation of Mouse Encephalomyelitis Virus.

Abstract

Various amino acids and analogs in concns. of 1-3 mg./ml. inhibit the propagation of Theiler''s GDVII strain of mouse encephalo-myelitis virus in tissue cultures of one-day-old mouse brain. The most active amino acid was L-lysine which was inhibitory at 0.5 mg./ml. The most effective analogs tested were the ortho-, meta-, or para-fluorophenylalanines, active at 0.1 mg./ml. Partial reversal of lysine inhibition of virus growth was obtained with methionine, leucine, or tyrosine.