A Novel Concept on the Pathogenetic Mechanism Underlying Ischaemic Brain Oedema: Relevance of Free Radicals and Eicosanoids
- 1 January 1987
- book chapter
- Published by Springer Nature in Acta Neurochirurgica Supplement
- Vol. 41, 85-94
- https://doi.org/10.1007/978-3-7091-8945-0_11
Abstract
A survey on literature reports and our own experimental studies on the pathogenetic mechanisms underlying ischaemic brain oedema is given and a new concept proposed. In regional incomplete ischaemia the lipoxygenase activity is enhanced, presumably caused by an increase of free radicals and hydroperoxides, leading to an enhancement of endothelial Na+, K+-ATPase and increased sodium and water transport from blood to brain. The aggravation of brain oedema and post-ischaemic hypoperfusion following recirculation appears to be mainly due to an activation of the cyclo-oxygenase pathway with release of oxidants from PGG2, which causes non-specific but detrimental damage to the endothelial and parenchymal cells. This new concept may open future perspectives in treatment which are briefly discussed.Keywords
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