Influence of Photodynamic Effects on Diffusion in Rabbit Dermis.

Abstract

Albino rabbits were intradermally injected in the left flank with equal amounts of Indian ink and hematoporphyrin solution, then exposed to light. Control injections of the same substance were symmetrically given on the right flank. For another group of animals diphtheria toxin was used instead of Indian ink. As a result of a photodynamic effect, a constant notable increase was observed in the diffusion of Indian ink and diphtheria toxin inoculated in the dermis. Since the spreading test may be assumed an indication of the conditions of the ground substance of dermal connective tissue, these results seem to demonstrate that after a photodynamic effect this substance is modified.