Phenytoin interacts with calcium channels in brain membrances
- 1 November 1984
- journal article
- case report
- Published by Wiley in Annals of Neurology
- Vol. 16 (5), 616-617
- https://doi.org/10.1002/ana.410160514
Abstract
Phenytoin at concentrations of between 30 and 300 μM inhibited binding of the calcium antagonist {3H} nitrendipine to voltage‐dependent calcium channels in brain membranes. Other anticonvulsants (phenobarbital, carbamazepine, valproic acid, and clonazepam) failed to inhibit binding or did so only at concentration much higher than occur clinically. Calcium channel blockade may be important in the clinical actions of phenytoin, including certain of the adverse effects of the drug.Keywords
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