THE RELATIONSHIP BETWEEN 5‐HYDROXYTRYPTAMINE AND ADENOSINE TRIPHOSPHATE IN BLOOD PLATELETS
Open Access
- 1 March 1958
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 13 (1), 62-64
- https://doi.org/10.1111/j.1476-5381.1958.tb00191.x
Abstract
In normal platelets a proportionality was found between the amount of adenosine triphosphate (ATP) and amount of 5-hydroxytryptamine (5-HT) in platelets both before and after incubating them in plasma to which 5-HT had been added. In patients receiving reserpine and in others with myeloid leukaemia, the amount of 5-HT in the platelets and the uptake of 5-HT by them were depressed, while the amount of ATP was normal. The possibility that ATP is involved in the accumulation of 5-HT by platelets is discussed.Keywords
This publication has 5 references indexed in Scilit:
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- Reserpine and human platelet 5-hydroxytryptamineCellular and Molecular Life Sciences, 1956
- Observations on the distribution of catechol amines and adenosinetriphosphate in the bovine adrenal medullaThe Journal of Physiology, 1956
- 5‐hydroxytryptamine in normal human plateletsThe Journal of Physiology, 1955
- Determination of ATP and Related Compounds: Firefly Luminescence and other MethodsPublished by Wiley ,1954