Metabolic and Growth Patterns in Transient Neonatal Diabetes

Abstract

In an infant born small for his gestational age, transient neonatal diabetes requiring insulin therapy for a three-month period developed. Initially, he had no insulin response to glucose and tolbutamide, but by three months of age, he showed a normal insulin response to glucose loading, which persisted into his second year of life. Institution of insulin therapy resulted in an accelerated growth rate, unusual in infants small for gestational age, which persisted beyond the period of insulin therapy.