Production of a Proteolytically Active Protein, Chlamydial Protease/Proteasome-Like Activity Factor, by Five Different Chlamydia Species

Abstract

We have previously identified a chlamydial protein, chlamydial protease/proteasome-like activity factor (CPAF), for degrading host transcription factors in cells infected with the human chlamydial species Chlamydia trachomatis or Chlamydia pneumoniae . We now report that functional CPAF was also produced during infection with the species Chlamydia muridarum , Chlamydia psittaci , and Chlamydia caviae , which primarily infect nonhuman hosts.