Mouse Red-Cell Rosettes in B-Lymphoproliferative Disorders
- 1 June 1976
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 33 (2), 173-177
- https://doi.org/10.1111/j.1365-2141.1976.tb03528.x
Abstract
Summary. A high proportion of peripheral-blood lymphocytes formed spontaneous rosettes with mouse red cells in 22 out of 23 cases of chronic lymphocytic leukaemia (CLL); the proportion was significantly higher than in 19 cases of other B-lymphoproliferative disorders (non-CLL group) and in 19 normal controls. Intermediate findings were obtained in 10 cases of ‘hairy’ cell leukaemia. Blast cells from various types of acute leukaemia did not bind mouse red cells. Pre-treatment of the lymphocytes with neuraminidase led to a significant increase in the proportion of rosettes in CLL only. This test may prove useful in distinguishing CLL from other B-lymphoproliferative disorders, particularly prolymphocytic leukaemia.This publication has 9 references indexed in Scilit:
- Hypothesis: differentiation of the human lymphoid system based on cell surface markersBlood, 1975
- Lymphocyte surface characteristics in malignant lymphomaAmerican Journal Of Medicine, 1975
- Surface IgD in Immunoproliferative DisordersScandinavian Journal of Immunology, 1974
- B-CELL NEOPLASIA IN MANThe Lancet, 1974
- Identification, Enumeration, and Isolation of B and T Lymphocytes from Human Peripheral BloodScandinavian Journal of Immunology, 1974
- FORMATION OF MOUSE OR SHEEP REDBLOOD-CELL ROSETTES BY LYMPHOCYTES FROM NORMAL AND LEUKÆMIC INDIVIDUALSThe Lancet, 1974
- ISOLATION OF NORMAL T CELLS IN CHRONIC LYMPHATIC LEUKÆMIAThe Lancet, 1973
- INTERACTION OF AGGREGATED γ-GLOBULIN WITH B LYMPHOCYTESThe Journal of Experimental Medicine, 1972
- IMMUNOGLOBULINS AS CELL RECEPTORS*Annals of the New York Academy of Sciences, 1971