The effect of structural aberrations of the chromosomes on reproductive fitness in man
- 1 September 1975
- journal article
- Published by Wiley in Clinical Genetics
- Vol. 8 (3), 159-168
- https://doi.org/10.1111/j.1399-0004.1975.tb01489.x
Abstract
Methods are presented to estimate relative fitness of carriers as a function of fertility, survival, are generation time in pedigrees under incomplete ascertainment. A large sample of diverse chromosomal aberrations reveals significant effects on all three parameters, giving a relative fitness of .769 +/- .039. There is no significant shift in segregation frequency. Implications of these results for population dynamics of structural rearrangements are discussed. The following paper applies these methods to specific classes of aberrations.Keywords
This publication has 4 references indexed in Scilit:
- The effect of structural aberrations of the chromosomes on reproductive fitness in manClinical Genetics, 1975
- The measurement of fitness and mutation rate in human populationsAnnals of Human Genetics, 1973
- Incidence and mutation rates of structural rearrangements of the autosomes in manAnnals of Human Genetics, 1972
- The inheritance of translocations in man: data from families ascertained through a balanced heterozygoteAnnals of Human Genetics, 1970