CONTROLLED FIELD TRIAL OF A TYPHOID VACCINE PREPARED WITH A NONMOTILE MUTANT OF SALMONELLA-TYPHI TY2
- 1 January 1975
- journal article
- research article
- Vol. 52 (1), 69-73
Abstract
A controlled field trial was performed in Egypt to evaluate a whole cell typhoid vaccine prepared with a nonmotile mutant of S. typhi Ty2 (TNM1) devoid of flagellar antigen. This vaccine did not elicit an H antibody response, but significant Vi and O agglutinin responses were observed. There were 34 typhoid cases among 21,063 6-7-yr-old children who received the TNM1 vaccine, and 44 cases among 21,017 children in the control group who received tetanus toxoid. TNM1 vaccine probably does not provide protection against typhoid fever. H antigen may be an important component of an effective vaccine.This publication has 9 references indexed in Scilit:
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