Studies on an Attenuated Measles-Virus Vaccine

Abstract

IN initial trials, the attenuated measles vaccine was given by subcutaneous injection, but the intact mucous membranes have certain practical and theoretical advantages to recommend them as a route of vaccination. In this study tests were carried out to compare the effectiveness of the subcutaneous route with other routes that might be involved in natural transmission of the disease. The object was to determine the infectivity of attenuated measles virus by naturally available routes both as a potential method of immunization and as a measure of the capacity of the virus to infect contacts of those vaccinated.On the basis . . .