Cytochemical localization of VIP-stimulated adenylate cyclase activity in human sweat glands
- 1 March 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 116 (3), 323-328
- https://doi.org/10.1111/j.1365-2133.1987.tb05845.x
Abstract
Vasoactive intestinal polypeptide (VIP)-stimulated adenylate cyclase was demonstrated cytochemically in human sweat glands. Biopsies containing axillary sweat glands were incubated with 5 .mu.m VIP and adenylate cyclase was demonstrated using the cerium-salt technique. Reaction products were localized in the plasma membranes of glandular and myoepithelial cells. Thus, VIP appears to stimulate adenylate cyclase activity without acetylcholine. VIP and acetylcholine in human sweat glands most probably act through a receptor complex, where adenylate cyclase is coupled to that part of the receptor stimulated by VIP.This publication has 18 references indexed in Scilit:
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