Effect of and Interaction Between Tranquilizers, Serotonin and Lysergic Acid Diethylamide on the Body Temperature of Pigeons
- 30 November 1958
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 195 (3), 751-754
- https://doi.org/10.1152/ajplegacy.1958.195.3.751
Abstract
The temperature responses of the pigeon to serotonin, reserpine, chlorpromazine and LSD-25 were investigated. It was demonstrated that a rapid hypothermia and depression follow the administration of all compounds except chlorpromazine. Serotonin, reserpine and chlorpromazine were shown to have certain prophylactic and therapeutic value on the LSD-25-induced hypothermia. The data indicate that a mutual antagonism exists in the interaction of these compounds. It is suggested that the mechanism of action of these drugs is quite complex, leading to mixed reactions, depending perhaps on what measurement is being considered.Keywords
This publication has 4 references indexed in Scilit:
- Effect of LSD-25 on Body Temperature of PigeonsAmerican Journal of Physiology-Legacy Content, 1958
- Hypothermia in the Rat, Hamster, Ground Squirrel and Pigeon Following ChlorpromazineAmerican Journal of Physiology-Legacy Content, 1958
- LSD-Like Effects Elicited by Reserpine in Rabbits Pretreated With Iproniazid.Experimental Biology and Medicine, 1957
- PRODUCTION OF ABNORMAL (PSYCHOTIC?) BEHAVIOR IN MICE WITH LYSERGIC ACID DIETHYLAMIDE, AND ITS PARTIAL PREVENTION WITH CHOLINERGIC DRUGS AND SEROTONINProceedings of the National Academy of Sciences, 1955