Studies on the Protective Effect of Gamma Globulin against Herpes Simplex Infections in Mice

Abstract

Concentrated human serum gamma globulin has been shown to contain virus neutralizing antibody for herpes simplex virus by means of protection tests in which mice were employed. When the globulin was administered prior to the challenge dose of virus the protective effect was definite although slight. No more than a minimal protective effect was observed when the viral injection preceded the administration of globulin by as little as 12 or 24 hours. Porcine and bovine gamma globulin had no demonstrable protective effect. No antigenic relationship between the viruses of herpes simplex and epidemic keratoconjunctivitis was revealed by protection tests with human gamma globulin.