Urea and deuterium-oxide spaces in man

Abstract
A method of determining the volume of distribution of urea after intravenous injection, by extrapolation to zero time, is presented. The urea space was compared with deuterium-oxide space determined at the same time in 6 men and 6 women. In all the subjects except one, the urea space was less than the deuterium-oxide space, the mean overall difference being 5.3%.