Effects of the Diethyl and Dimethyl Esters of Glutamic Acid on Morphine Anti-nociception in the Rat

Abstract

The effects of pretreatments with various doses of glutamic acid diethyl or dimethyl esters on morphine-induced anti-nociception in the hot-plate and tail-flick tests on rats were examined. While neither substance alone altered control reaction times, they both antagonized the effects of morphine, suggesting the possible involvement of glutamate receptors in narcotic ";analgesia". However, several aspects of the data inveigh against the significance of the findings with regard to narcotic mechanisms.