dATP accumulation and ATP depletion in platelets in adenosine deaminase deficiency: Significance for the immune response?
- 1 October 1984
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 4 (10), 809-818
- https://doi.org/10.1007/bf01138162
Abstract
High levels of dATP and dADP, accompanied by ATP depletion, were found in the platelets of two ADA-deficient children with severe combined immunodeficiency (SCID). In vitro studies demonstrated that even normal platelets had the ability to make dATP from deoxyadenosine (dAR) under physiological conditions. This capability was greatly enhanced by conditions simulating ADA deficiency. These results question whether the platelet has a specific role in the normal immune response.Keywords
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