METABOLISM IN VITRO OF TRITIATED ADRENOCORTICOTROPIC HORMONE
- 31 August 1965
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 43 (9), 1489-1498
- https://doi.org/10.1139/o65-167
Abstract
Adrenocorticotrophic hormone (ACTH) labeled with tritium has been prepared with a specific radioactivity of approximately 4000 d.p.m./μg. The tritiated trophin showed biological activity and appeared to be bound to the cells of the adrenal gland. Data indicating that the adrenal cortex can inactivate ACTH were obtained; whether such inactivation is due to binding or enzymatic degradation has not been illustrated. Attempts to demonstrate that the adrenal gland could acetylate the N-terminal serine residue of ACTH failed.This publication has 7 references indexed in Scilit:
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- THE RESISTANCE OF THYROTROPHIC AND ADRENOCORTICOTROPHIC HORMONES TOWARDS PURIFIED THYROID AND ADRENAL PROTEINASES1Endocrinology, 1959
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