EFFECTS OF APOMORPHINE, ERGOCORNINE AND PIRIBEDIL ON AUDIOGENIC SEIZURES IN DBA/2 MICE

Abstract

Audiogenic seizures in DBA/2 mice have been studied after administration of drugs believed to act as dopamine agonists. Apomorphine at 0.4 mg/kg delays all phases of the response, the tonic phase is absent after 2.0 mg/kg; the clonic phase is abolished by 10 mg/kg. Ergocornine (0.5–8.0 mg/kg) produces effects on the latency and occurrence of seizure stages similar to those of apomorphine. Piribedil, ET 495 (4–100 mg/kg) is less potent; even after 100 mg/kg clonic and tonic phases occurred in 50% of the mice.