Visual cortex in dementia with Lewy bodies: Magnetic resonance imaging study
Open Access
- 1 June 2012
- journal article
- research article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 200 (6), 491-498
- https://doi.org/10.1192/bjp.bp.111.099432
Abstract
Background Visual hallucinations and visuoperceptual deficits are common in dementia with Lewy bodies, suggesting that cortical visual function may be abnormal. Aims To investigate: (1) cortical visual function using functional magnetic resonance imaging (fMRI); and (2) the nature and severity of perfusion deficits in visual areas using arterial spin labelling (ASL)-MRI. Method In total, 17 participants with dementia with Lewy bodies (DLB group) and 19 similarly aged controls were presented with simple visual stimuli (checkerboard, moving dots, and objects) during fMRI and subsequently underwent ASL-MRI (DLB group n = 15, control group n = 19). Results Functional activations were evident in visual areas in both the DLB and control groups in response to checkerboard and objects stimuli but reduced visual area V5/MT (middle temporal) activation occurred in the DLB group in response to motion stimuli. Posterior cortical perfusion deficits occurred in the DLB group, particularly in higher visual areas. Conclusions Higher visual areas, particularly occipito-parietal, appear abnormal in dementia with Lewy bodies, while there is a preservation of function in lower visual areas (V1 and V2/3).Keywords
This publication has 44 references indexed in Scilit:
- Visual hallucinations in dementia with Lewy bodies: transcranial magnetic stimulation studyThe British Journal of Psychiatry, 2011
- Age-related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labelingJournal of Magnetic Resonance Imaging, 2011
- Development of a Novel fMRI Compatible Visual Perception Prototype Battery to Test Older People With and Without DementiaJournal of Geriatric Psychiatry and Neurology, 2011
- Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction?Brain Imaging and Behavior, 2010
- Nicotinic α4β2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinationsNeuroImage, 2008
- Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodiesNuclear Medicine Communications, 2007
- Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's diseaseBrain, 2007
- Occipital Glucose Metabolism in Dementia with Lewy Bodies with and without Parkinsonism: A Study Using Positron Emission TomographyDementia and Geriatric Cognitive Disorders, 2001
- The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment ScaleThe British Journal of Psychiatry, 2000
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975