Evidence for Humoral Factors in Renoprival Hypertension

Abstract

Plasma of renoprival hypertensive rats was found to have an exaggerated constrictor effect on isolated rat aorta strips, however, no pressor effect was produced in acutely nephrectomized rats cross-circulated with renoprival hypertensive animals. It is suggested that if the constrictor element of the plasma from renoprival hypertensive rats is not just an artifact of the aorta strip assay technic but does exist and play a role in renoprival hypertension, it does so by acting on arterioles sensitized by the chronic a-renal condition.