Inhibition of ADAM-TS4 and ADAM-TS5 Prevents Aggrecan Degradation in Osteoarthritic Cartilage
Open Access
- 1 June 2002
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 277 (25), 22201-22208
- https://doi.org/10.1074/jbc.m200431200
Abstract
No abstract availableKeywords
This publication has 48 references indexed in Scilit:
- Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal TruncationPublished by Elsevier ,2002
- Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivoBiochemical Journal, 2001
- The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradationOsteoarthritis and Cartilage, 2001
- The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1Biochemical Journal, 2000
- Characterization of Aggrecan Retained and Lost from the Extracellular Matrix of Articular CartilageJournal of Biological Chemistry, 1998
- Degradation of cartilage aggrecan by collagenase‐3 (MMP‐13)FEBS Letters, 1996
- Cell-mediated Catabolism of AggrecanPublished by Elsevier ,1995
- Quantitative criteria for evaluating the early development of osteoarthritis and the effect of diclofenac sodiumInflammation Research, 1989
- Spontaneous cartilage degeneration in guinea pigsArthritis & Rheumatism, 1988
- Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the kneeArthritis & Rheumatism, 1986