Synthesis of Isoxazolidino Analogues of 2′,3′-Dideoxynucleosides
- 1 April 1999
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 18 (4-5), 581-583
- https://doi.org/10.1080/15257779908041501
Abstract
The complete set of the 4′-aza analogues of 2′,3′-dideoxynucleosides was synthesized by cycloaddition of N-tetrahydropiranyl or N-trityl methylene nitrones on suitably protected vinyl nucleobases. The convertible nucleoside approach was used in the preparation of cytosine and 5-methyl cytosine analogues.Keywords
This publication has 6 references indexed in Scilit:
- A Novel Class of 4′-Aza Analogues of 2′,3′-Dideoxynucleosides as Potential Anti-HIV DrugsNucleosides and Nucleotides, 1997
- Model studies towards the synthesis of 4′-azaerythrofuranosyladenines as analogues of the antiviral drug 2′,3′-dideoxyadenosine (ddA) 1Journal of the Chemical Society, Perkin Transactions 1, 1997
- Synthesis of Two 6-N-Protected 9-N-Vinyladenines as Dipolarophiles in the Synthesis of Modified NucleosidesSynthetic Communications, 1996
- Synthesis of 4′-aza analogues of 2′,3′-dideoxythymidine by 1,3-dipolar cycloadditions of nitrones to 1-N-vinyl-thymineTetrahedron Letters, 1996
- Synthesis of Pyrimidine 2′,3′-Dideoxy-2-ThionucleosidesNucleosides and Nucleotides, 1995
- Highly water-soluble lipophilic prodrugs of the anti-HIV nucleoside analog 2',3'-dideoxycytidine and its 3'-fluoro derivativeJournal of Medicinal Chemistry, 1992