Three cases of congenital agenesis of the corpus callosum (ACC) are presented along with typical clinical features observed on computerized tomography and magnetic resonance imaging. Most congenital ACC cases do not display hemisyndromes or callosal syndromes, but do exhibit some deficit in terms of hemispheric integration. The most common neuropsychological impairments are in the areas of motor and perceptual-motor functioning. Clinical guidelines in the assessment of ACC patients are given