An IL-8 gene promoter polymorphism is associated with the risk of the development of AIDS-related Kaposi's sarcoma
- 1 May 2004
- journal article
- Published by Wolters Kluwer Health in AIDS
- Vol. 18 (8), 1206-1208
- https://doi.org/10.1097/00002030-200405210-00016
Abstract
In a case-control study, we studied the effect of a single nucleotide polymorphism in the IL-8 promoter on the risk of the development of AIDS-related Kaposi's sarcoma (KS). KS developed in 46% of individuals with the TT genotype and in 66% of AA/AT genotypes (P=0.038). Patients with TT genotype were rarely affected with visceral KS (7% versus 36%; P=0.06), which suggests that carriers of the TT genotype are protected from (severe) KS development.Keywords
This publication has 6 references indexed in Scilit:
- Genetic Susceptibility to EnteroaggregativeEscherichia coliDiarrhea: Polymorphism in the Interleukin‐8 Promotor RegionThe Journal of Infectious Diseases, 2003
- Substantial changes in gene expression level due to the storage temperature and storage duration of human whole bloodClinical and Laboratory Haematology, 2002
- Interleukin-8 and Growth-Regulated Oncogene Alpha Mediate Angiogenesis in Kaposi's SarcomaJournal of Virology, 2002
- Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK familiesThorax, 2000
- An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virusBlood, 2000
- Elevated serum levels of IL-8 in patients with HIV infectionClinical and Experimental Immunology, 1993