A proteomic snapshot of the human heat shock protein 90 interactome
- 24 October 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (28), 6350-6354
- https://doi.org/10.1016/j.febslet.2005.10.020
Abstract
Heat shock protein 90 (Hsp90) is a molecular chaperone which modulates several signalling pathways within a cell. By applying co‐immunoprecipitation with endogeneous Hsp90, we were able to identify 39 novel protein interaction partners of this chaperone in human embryonic kidney cells (HEK293). Interestingly, levels of DNA‐activated protein kinase catalytic subunit, an Hsp90 interaction partner found in this study, were found to be sensitive to Hsp90 inhibitor treatment only in HeLa cells but not in HEK293 cells referring to the tumorgenicity of this chaperone.This publication has 30 references indexed in Scilit:
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