Thyroid suppression test with serum thyroxine concentration as index of suppression

Abstract

A thyroid suppression test is suggested which relies on the change in concentration of serum thyroxine as the index of thyroid response to the administration of triiodothyronine. The test has been carried out in 16 healthy volunteers and in 27 patients referred for routine suppression tests. This index appears to be sensitive and safe and results in a reduction in the required dosage of triiodothyronine. The test can be carried out in fewer patient-visits than the commonly used suppression test; moreover, in remote areas the patient need not attend the specialist centre because the course of triiodothyronine can be given (and the serum samples obtained) locally, the samples then being sent to the appropriate laboratory for assay.