Incorporation of oxygen-18 into the 25-position of cholecalciferol by hepatic cholecalciferol 25-hydroxylase
- 1 November 1978
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 175 (2), 479-482
- https://doi.org/10.1042/bj1750479
Abstract
The oxygen enzymically inserted as a hydroxy function by rat liver post-mitochondrial fraction into the 25-position of cholecalciferol to giver 25-hydroxycholecaliferol is derived exclusively from molecular O2. Therefore like the other two cholecalciferol hydroxylases, i.e. 25-hydroxycholecalciferol 1alpha-hydroxylase and 25-hydroxycholecalciferol 24-hydroxylase, the cholecalciferol 25-hydroxylase is also a mono-oxygenase (‘mixed-function oxidase’).This publication has 14 references indexed in Scilit:
- Mechanism of 25-hydroxyvitamin D3 24-hydroxylation: incorporation of oxygen-18 into the 24 position of 25-hydroxyvitamin D3Biochemistry, 1977
- Vitamin D: the vitamin and the hormone.1974
- Mitochondrial cytochrome p450. A component of chick kidney 25-hydrocholecalciferol-1alpha-hydroxylase.1974
- The story of vitamin D: from vitamin to hormone.1974
- 25-Hydroxycholecalciferol-1-hydroxylase: A specific requirement for NADPH and a hemoprotein component in chick kidney mitochondriaArchives of Biochemistry and Biophysics, 1974
- Subcellular location of rat liver calciferol-25-hydroxylaseArchives of Biochemistry and Biophysics, 1974
- Vitamin D3-25-hydroxylase: Tissue occurrence and apparent lack of regulationArchives of Biochemistry and Biophysics, 1973
- A new chromatographic system for vitamin D3 and its metabolites: resoluation of a new vitamin D3 metabolite.1971
- In vitro production of 25-hydroxycholecalciferolBiochemical and Biophysical Research Communications, 1969
- 25-Hydroxycholecalciferol. A biologically active metabolite of vitamin D3Biochemistry, 1968