The Effects of Inhibitors of Macromolecular Biosynthesis upon the Persistent Rhythm of Luminescence in Gonyaulax
Open Access
- 1 September 1963
- journal article
- research article
- Published by Rockefeller University Press in The Journal of general physiology
- Vol. 47 (1), 1-12
- https://doi.org/10.1085/jgp.47.1.1
Abstract
Certain inhibitors of nucleic acid and protein synthesis, namely actinomycin D, mitomycin C, and puromycin, have been found to block the expression of a persistent daily rhythm of bioluminescence. The action does not inhibit luminescence per se but rather the rhythmicity. Exposure of the cells to these inhibitors for only a few hours, which might be expected to thereby delay the rhythm by a few hours, does not in fact have this effect. Chloramphenicol and amethopterin do not inhibit the rhythm. It is proposed that the functioning of the clock-like rhythmic mechanism depends upon the cell''s normal ability to synthesize RNA.Keywords
This publication has 22 references indexed in Scilit:
- Origin and Biologic Individuality of the Genetic DictionaryScience, 1962
- THE INHIBITION OF A BIOLOGICAL CLOCK BY ACTINOMYCIN DProceedings of the National Academy of Sciences, 1962
- THE IDENTIFICATION OF THE RIBOSOMAL RNA CISTRON BY SEQUENCE COMPLEMENTARITY, I SPECIFICITY OF COMPLEX FORMATIONProceedings of the National Academy of Sciences, 1962
- RNA metabolism in Escherichia coli infected with bacteriophage T4: Inhibition of host ribosomal and soluble RNA synthesis by phage and effect of chloromycetinJournal of Molecular Biology, 1962
- Mechanism of puromycin inhibition of hemoglobin synthesisBiochemical and Biophysical Research Communications, 1962
- Inhibition of polypeptide synthesis by streptomycinBiochemical and Biophysical Research Communications, 1962
- Unstable Ribonucleic Acid Revealed by Pulse Labelling of Escherichia ColiNature, 1961
- Biochemical Aspects of Rhythms: Phase Shifting by ChemicalsCold Spring Harbor Symposia on Quantitative Biology, 1960
- Zur Wirkungsweise von ActinomycinenHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1960
- INHIBITION BY PUROMYCIN OF AMINO ACID INCORPORATION INTO PROTEINProceedings of the National Academy of Sciences, 1959