The Clearance of Antigen Antibody Complexes from the Blood by the Reticulo-Endothelial System
Open Access
- 1 February 1959
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 82 (2), 131-137
- https://doi.org/10.4049/jimmunol.82.2.131
Abstract
Summary: Soluble complexes of antigens with rabbit antibody interfere by a phenomenon of competition with the phagocytosis of carbon particles by the reticuloendothelial system, when injected intravenously into mice and rabbits. Evidence is presented that at least the larger soluble antigen-antibody aggregates are phagocytized by the Kupffer cells of the liver. The significance of these findings is discussed in relation to the localization of antigen-antibody complexes in the sites of pathologic lesions of serum sickness.Keywords
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