α5β1 integrin mediates strong tissue cohesion
Open Access
- 15 January 2003
- journal article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 116 (2), 377-386
- https://doi.org/10.1242/jcs.00231
Abstract
Integrins and cadherins are considered to have distinct and opposing functions. Integrins are traditionally cited for their role in cell-substratum interactions, whereas cadherins are thought to mediate strong intercellular cohesion. Together, these adhesion systems play crucial roles in a wide variety of cellular and developmental processes including cell migration, morphology, differentiation and proliferation. In this manuscript we present evidence that integrins possess the ability to mediate strong intercellular cohesion when cells are grown as 3D aggregates.Keywords
This publication has 37 references indexed in Scilit:
- Cell Adhesion Proteins As Tumor SuppressorsJournal of Urology, 2002
- A novel fibronectin binding site required for fibronectin fibril growth during matrix assemblyThe Journal of cell biology, 2001
- Kinetic Determination of Focal Adhesion Protein FormationBiochemical and Biophysical Research Communications, 2000
- Requirements for α5β1Integrin-mediated Retraction of Fibronectin-Fibrin MatricesPublished by Elsevier ,1999
- Cell-binding Peptides Conjugated to Poly(ethylene glycol) Promote Neural Cell AggregationNature Biotechnology, 1994
- Integrins: Versatility, modulation, and signaling in cell adhesionCell, 1992
- Identification of the fibronectin sequences required for assembly of a fibrillar matrix.The Journal of cell biology, 1991
- Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cellsCell, 1990
- Development of a Competitive Radioimmunoassay for Human Plasma FibronectinInternational Archives of Allergy and Immunology, 1986
- Role of cell shape in growth controlNature, 1978