Familial Occurrence of Letterer-Siwe Disease
Open Access
- 1 February 1972
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 47 (251), 122-125
- https://doi.org/10.1136/adc.47.251.122
Abstract
Letterer-Siwe disease occurred in 4 infant sibs from two consanguineous families. An identical clinical course and pathological picture was observed in all 4 infants. The occurrence of families with multiple cases supports the hypothesis of genetic causation in Letterer-Siwe disease. The family patterns are in accord with an autosomal recessive inheritance.Keywords
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