Novel C–C bond formation at the 5-position of uracils. Facile synthesis of 5-methoxycarbonylmethyluridine and 5-carbamoylmethyluridine, minor component nucleosides derived from transfer ribonuclease

Abstract

5-Hydroxyuracil derivatives were treated with stable Wittig reagents to give the corresponding 5-alkyluracil derivatives such as 5-methoxycarbonylmethyl-uridine and 5-carbamoylmethyluridine.