Specific inhibition of hepatic fatty acid synthesis exerted by dietary linoleate and linolenate in essential fatty acid adequate rats
- 1 June 1976
- Vol. 11 (6), 485-490
- https://doi.org/10.1007/bf02532840
Abstract
Dietary linoleate and linolenate were investigated for their ability to specifically inhibit liver and adipose tissue lipogenesis in meal-fed (access to food 900-1,200 hr), essential fatty acid (EFA) adequate rats. Supplementing a high carbohydrate diet containing 2.5% safflower oil with 3% palmitate 16∶0, oleate 18∶1, or linoleate 18∶2 did not affect in vivo liver or adipose tissue fatty acid synthesis. However, 18∶2 addition to the basal diet did result in a significant (P<0.05) decline of liver fatty acid synthetase (FAS) and glucose-6-phosphate dehydrogenase (G6PD) activities. When the safflower oil content of the basal diet was reduced to 1%, the addition of 3% 18∶2 or linolenate 18∶3 significantly (P<0.05) depressed hepatic FAS, G6PD, and in vivo fatty acid synthesis by 50%. Addition of 18∶1 caused no depression in hepatic FAS activity but did result in a significant (P<0.05) decline in liver G6PD activity and fatty acid synthesis which was intermediate between basal and basal +18∶2-or+18∶3-fed animals. Adipose tissue rates of lipogenesis were completely unaffected by dietary fatty acid supplementation. Similarly, the addition of 3 or 5% 18∶3 to a basal diet for only one meal resulted in no change in lipogenesis relative to that in animals fed the basal diet. The data indicate that, like rats fed EFA-deficient diets, dietary 18∶2 and 18∶3 exert a specific capacity to depress rat liver FAS and G6PD activities and rate of fatty acid synthesis.This publication has 19 references indexed in Scilit:
- Influence of Dietary Safflower Oil and Tallow on Growth, Plasma Lipids and Lipogenesis in Rats, Pigs and ChicksExperimental Biology and Medicine, 1975
- Influence of dietary fatty acids on membrane properties and enzyme activities of liver mitochondria of normal and hypophysectomized ratsLipids, 1975
- Effect of exogenous polyunsaturated fatty acids on lipogenic enzyme activity in rat liver under fixed carbohydrate consumption.Journal of Nutritional Science and Vitaminology, 1975
- Comparison of α-linolenate and oleate in lowering activity of lipogenic enzymes in rat liver: Evidence for a greater effect of dietary linolenate independent of food and carbohydrate intakeBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1974
- The effect of unsaturated fatty acids on the rate of synthesis of rat liver glucose-6-phosphate dehydrogenaseBiochimica et Biophysica Acta (BBA) - General Subjects, 1972
- Selective dampening of lipogenic enzymes of liver by exogenous polyunsaturated fatty acidsBiochemical and Biophysical Research Communications, 1970
- Dietary unsaturated fatty acids and liver fatty acid synthetase in ratsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969
- LIPOGENESIS IN ADIPOSE TISSUE OF MEAL-FED RATS: A POSSIBLE REGULATORY ROLE OF α-GLYCEROPHOSPHATE FORMATIONCanadian Journal of Physiology and Pharmacology, 1967
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951