Androgens in Patients with Benign Prostatic Hyperplasia Before and After Prostatectomy

Abstract

Plasma androgens [testosterone (T), 17β-hydroxy-5α-androstan-3-one (DHT), androst-4- en-3,17 dione(A), and dehydroepiandrosterone (DHEA)] as well as 17 hydroxyprogesterone were measured in a group of patients (age 60–80 yrs.) with benign prostatic hyperplasia (BPH) just before prostatectomy and compared to values obtained in subjects of similar age without signs of BPH. The most important difference was observed in the mean DHT level which was significantly (P < 0.025) higher than in the control group; mean T and free testosterone levels in BPH patients were slightly higher (P<0.05) in the age group 70–80 yrs; whereas in age group 60–70 mean values were similar to those observed in normal controls. Mean A, DHEA and 17 OHP and E2 levels were not significantly different in BPH patients when compared to age matched controls. 2–5 months after prostatectomy, T and DHT levels were significantly higher than immediately preoperatively. The preoperative stress may have influenced the preprostatectomy values.