ENHANCEMENT OF ACETYLCHOLINE-EVOKED CATECHOLAMINE RELEASE FROM PERFUSED DOG ADRENALS BY ELEVATING CYCLIC-AMP LEVELS
- 1 January 1985
- journal article
- research article
- Vol. 275 (2), 208-216
Abstract
Guanylyl-imidodiphosphate, guanosine 5''-tetraphosphate and phosphodiesterase inhibitors, 3-isobutyl-1-methylxanthine and RO 20-1724 significantly increased the basal cAMP output and caused a slight catecholamine (CA) release in dogs. These agents accelerated ACh-induced increase in cAMP ouput followed by a markedly enhanced CA release. Cholera toxin did not cause CA release but markedly enhanced ACh-evoked CA release. cAMP apparently plays a modulating role in CA release from chromaffin cells.This publication has 10 references indexed in Scilit:
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